- Author
-
R.S. Schluter
- Title
- Stimulation of the addicted brain
- Subtitle
- Magnetic stimulation as add-on treatment for alcohol use disorder
- Supervisors
-
A.E. Goudriaan
- Co-supervisors
-
R.J. van Holst
- Award date
- 5 June 2020
- Number of pages
- 295
- ISBN
- 9789402820256
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Non-invasive neuromodulation (i.e. transcranial Electric Stimulation and Transcranial Magnetic Stimulation) has become increasingly popular. These techniques are able to manipulate neural activity and thereby potentially affect behavior and executive functioning. It is for this reason that non-invasive neuromodulation, including TMS, is studied as novel add-on treatment for alcohol and substance use disorders, a disorder with frequent diminished executive functioning. In this thesis, Renée Schluter investigated the effect of non-invasive neuromodulation on executive functioning in healthy individuals and patients with a substance use disorder. Furthermore she studied Transcranial Magnetic Stimulation as add-on treatment for alcohol use disorder.
The main findings presented in this thesis can be summarized as follows: first, in healthy individuals non-invasive neuromodulation only affected impulse control, other executive functioning domains (such as working memory and flexibility) were not affected. Furthermore, one single session of TMS changed resting state functional connectivity in the salience network. These results indicate small and specific effects of non-invasive neuromodulation in healthy individuals. Second, the reviewed effects of noninvasive neuromodulation on executive functions in substance use disorder studies were inconclusive. This was caused by variety in stimulation protocols and behavioral task paradigms, which impaired proper comparisons. Third, TMS add-on treatment did not affect executive functions in patients with an alcohol use disorder in treatment. Add-on treatment also did not affect relapse rates and experienced craving six months after treatment. Future preregistered multicenter randomized controlled clinical trials are required in order to substantiate evidence on effects of TMS add-on treatment in substance use disorders. - Persistent Identifier
- https://hdl.handle.net/11245.1/f2ec3355-cd07-4d35-8456-bc8020c444bb
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: The effect of non-invasive brain stimulation on executive functioning in healthy controls: A systematic review and meta- analysis
Chapter 3: Differential effects of left and right prefrontal high-frequency repetitive transcranial magnetic stimulation on resting-state functional magnetic resonance imaging in healthy individuals
Chapter 4: Effects of non-invasive neuromodulation on executive and other cognitive functions in addictive disorders: A systematic review
Chapter 5: Repetitive Transcranial Magnetic Stimulation (rTMS) in alcohol dependence: Study protocol of a randomized controlled clinical trial of efficacy and working mechanisms
Chapter 6: Effects of ten sessions of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) add-on treatment on impulsivity in alcohol use disorder
Chapter 7: Effects of ten High Frequency Transcranial Magnetic Stimulation (HF-rTMS) add-on treatment sessions on flexibility and working memory in alcohol use disorder
Chapter 8: Clinical effect of ten HF-rtTMS add-on treatment sessions on relapse and craving in alcohol use disorder: Results of a sham controlled single blind randomized controlled clinical trial
Chapter 9: Summary and general discussion
References; Nederlandse samenvatting; PhD portfolio; List of publications; Dankwoord
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