- Author
-
M. Muilwijk
- Title
- Lipotoxicity and type 2 diabetes in South Asians
- Supervisors
-
K. Stronks
- Co-supervisors
- Award date
- 14 April 2020
- Number of pages
- 201
- ISBN
- 9789463758154
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
People of South Asian ethnicity are at higher risk of type 2 diabetes (T2D) than people of European origin. The underlying causes for the higher susceptibility remain hard to pinpoint. A novel mechanism suggested to play a role in the pathophysiology of T2D is lipotoxicity. The ultimate aim of this thesis was to identify targets to prevent T2D among South Asians specifically those related to dietary fat intake and ensuing lipotoxicity. Altogether, the studies included in this thesis confirmed that lipotoxicity is an underlying mechanism leading to T2D. Although incorporating strategies related to lipotoxicity-related mechanisms may decrease T2D risk, these will not likely decrease relative ethnic differences in T2D risk. Some leads that may explain the high T2D risk among South Asians independent of lipotoxicity were identified, and may be further explored in future studies.
- Persistent Identifier
- https://hdl.handle.net/11245.1/ea53d6a5-6796-4565-8e5f-b073e38562c2
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Plasma cholesteryl ester fatty acids do not mediate the association of ethnicity with type 2 diabetes: Results from the HELIUS study
Chapter 3: The association of acylcarnitines and amino acids with age in Dutch and South-Asian Surinamese living in Amsterdam
Chapter 4: Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults
Chapter 5: The high risk for type 2 diabetes among ethnic minority populations is not explained by low-grade inflammation
Chapter 6: Dietary and physical activity strategies to prevent type 2 diabetes in South Asian adults: Protocol for a systematic review
Chapter 7: Dietary and physical activity recommendations to prevent type 2 diabetes in South Asian adults: A systematic review
Chapter 8: General discussion
Summary; Samenvatting; PhD portfolio; List of publications; Dankwoord; About the author
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