- Author
-
E.F.E. Wenstedt
- Title
- Our body of salt
- Subtitle
- Tracking the traces of sodium from blood to skin
- Supervisors
-
J.J. Homan van der Heide
- Co-supervisors
-
L. Vogt
B.J.H. van den Born - Award date
- 4 November 2020
- Number of pages
- 213
- ISBN
- 9789464025064
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Average global salt intake is more than double the amount that is recommended by guidelines (5 grams of sodium chloride per day). An amount of 3 million deaths per year worldwide is estimated to be attributable to high salt intake. For such a major health issue, it may come as a surprise that the underlying mechanisms are less well established than one might expect. Studies that more closely investigate the classical notion that salt leads to high blood pressure and other worse outcomes via water retention and consequential volume effects, do not seem to hold their ground.
Therefore, this thesis aimed to reevaluate the effects that high salt intake has throughout the human body. First, we closely reexamined classical theories based on volume retention and vascular resistance. Then, we explored more recent notions, involving the possibility of (skin) sodium storage and coinciding changes in immune cells, microcirculation, and glycosaminoglycans. The chapters of this thesis consecutively discuss these phenomena along the path that sodium undertakes from blood to skin, leaving its marks in each compartment. - Persistent Identifier
- https://hdl.handle.net/11245.1/c802c853-1039-4c42-a66a-6f27b99c7a92
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: Introduction and outline of this thesis
Chapter 2: Sodium handling by the blood vessel wall: Critical for hypertension development
Chapter 3: The effect of high salt diet on blood pressure and body fluid composition in type 1 diabetes patients: A randomized controlled intervention trial
Chapter 4: Salt-sensitive blood pressure rise in type 1 diabetes patients is accompanied by disturbed skin macrophage influx and lymphatic dilation: A proof-of-concept study
Chapter 5: Salt increases monocyte CCR2 expression and inflammatory responses in humans
Chapter 6: The effect of macrophage-targeted interventions on blood pressure: A systematic review and meta-analysis of preclinical studies
Chapter 7: The effect of high salt diet on T-lymphocyte subsets in healthy males: A pilot study
Chapter 8: Relationship of estimated sodium intake with granulocytes, renal and cardiovascular outcomes in the epic-norfolk prospective population study
Chapter 9: High salt intake affects retinal vascular tortuosity in healthy males: An exploratory randomized cross-over trial
Chapter 10: Distinct osmoregulatory responses in patients with altered glycosaminoglycan structure
Chapter 11: Summary and perspectives
Nederlandse samenvatting; Authors and affiliations; About the author; Portfolio; Dankwoord
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