- Author
-
A.L. Moekotte
- Title
- Improving outcomes of minimally invasive pancreas surgery and ampullary cancer
- Supervisors
-
M.G.H. Besselink
M. Abu Hilal - Co-supervisors
-
J.W. Wilmink
- Award date
- 11 September 2020
- Number of pages
- 232
- ISBN
- 9789463809177
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Ampullary adenocarcinoma is a rare tumor that arises from the ampulla of Vater; the confluence of the common bile duct and the pancreatic duct. It represent a heterogeneous group with considerable morphological heterogeneity and therefore, a broad range of survival rates. The only potential curative treatment is surgical resection through a pancreatoduodenectomy, a major procedure with high morbidity- and mortality rates. The role of adjuvant chemotherapy in ampullary adenocarcinoma is unclear. Given the rarity of ampullary adenocarcinomas, no single randomized clinical trial in adjuvant treatment has focused specifically on ampullary adenocarcinoma. The research in this thesis aims to improve the surgical aspect of the treatment, through minimally invasive pancreas surgery, with the focus on implementation and safety. Another pillar of this thesis is improving the prediction of survival after resection of ampullary adenocarcinomas by defining predictors of survival and recurrence as well as developing a prediction model to anticipate 3- and 5-year survival of individual patients. Lastly, the role of adjuvant chemotherapy in ampullary adenocarcinoma is investigated.
- Persistent Identifier
- https://hdl.handle.net/11245.1/bccc4f3f-ae8d-42be-9add-e36bf7d34e8d
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and thesis outline
Chapter 2: The Miami International Evidence-Based Guidelines on Minimally Invasive Pancreas Resection
Chapter 3: Safe implementation of minimally invasive pancreas resection: A systematic review
Chapter 4: Multicentre observational cohort study of implementation and outcomes of laparoscopic distal pancreatectomy
Chapter 5: Splenic preservation versus splenectomy in laparoscopic distal pancreatectomy: A propensity score matched study
Chapter 6: Autogenic splenic implantation versus splenectomy in patients undergoing distal pancreatectomy for benign or low-grade malignant lesions: Study protocol for a multicenter, randomized controlled trial (RESTORE
Chapter 7: Comparing robotic, laparoscopic, and open pancreatoduodenectomy for ampullary adenocarcinoma: An international multicenter cohort study
Chapter 8: Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma: International multicenter cohort study
Chapter 9: Benefit of gemcitabine-based adjuvant chemotherapy in the subtypes of resected ampullary adenocarcinoma: An international propensity-score matched cohort study
Chapter 10: Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma
Concluding remarks
Nederlandse samenvatting; List of contributing authors; PhD portfolio; List of publications; Curriculum vitae; Acknowledgements (dankwoord)
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