- Author
-
S. Mintjens
- Title
- Periconceptional influences on childhood cardiometabolic health
- Supervisors
-
T.J. Roseboom
R.J.B.J. Gemke - Award date
- 13 May 2020
- Number of pages
- 201
- ISBN
- 9789464021592
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
A body of observational evidence and animal experiments have linked maternal obesity before and during pregnancy to poorer cardiometabolic health in offspring, and altering the early embryo by means of assisted reproductive technology (ART) treatment also affected offspring’s cardiometabolic health. Potentially, improving the in utero environment by optimizing maternal lifestyle and body mass index (BMI) may mitigate the negative effects of maternal obesity on children’s health. Currently, only human lifestyle interventions during pregnancy have been completed and were unable to induce lasting effects on childhood cardiometabolic health. Hence, there is an opportunity for interventions to optimize maternal lifestyle before conception. Additionally, there have been no previous randomized controlled trials that examined whether hormonal stimulation or in vitro fertilization (IVF) procedures differently affect children’s health. To that end, the studies described in this thesis aimed to elucidate the effects of periconceptional influences on children’s cardiometabolic health, and experimentally assess whether a preconception lifestyle intervention or different fertility treatments may affect cardiometabolic health in the offspring.
- Persistent Identifier
- https://hdl.handle.net/11245.1/b70969e3-a31f-4b86-9da7-89585f639410
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies
Chapter 3: Maternal prepregnancy overweight and obesity are associated with reduced physical fitness but do not affect physical activity in childhood: The Amsterdam Born Children and their Development study
Chapter 4: Cardiorespiratory fitness in childhood and adolescence affects future cardiovascular risk factors: A systematic review of longitudinal studies
Chapter 5: The effects of a preconception lifestyle intervention on childhood cardiometabolic health: Follow-up of a randomized controlled trial
Chapter 6: The effects of intrauterine insemination and single embryo transfer or modified natural cycle in vitro fertilization on offspring’s health: Follow-up of a randomized clinical trial
Chapter 7: General discussion
Chapter 8: English summary
Chapter 9: Nederlandse samenvatting
Abbreviations; Supplement; Portfolio; Co-authors; Publications; Dankwoord; Curriculum vitae
Stellingen
- Supplementary materials
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.