- Author
-
E.R.C. Hagens
- Title
- Esophageal cancer treatment
- Subtitle
- Predicting and improving short- and long-term outcomes
- Supervisors
- Co-supervisors
-
S.S. Gisbertz
- Award date
- 9 October 2020
- Number of pages
- 487
- ISBN
- 9789463809139
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Esophageal cancer is a very aggressive disease and is becoming more common, particularly in the Western world. Having lymph node metastasis is one of the most important factors predicting the prognosis of a patient with esophageal cancer. The lymphogenic metastasis pattern of patients with esophageal cancer is unknown and therefore the optimal radiotherapeutic and surgical treatment with regard to the lymph nodes is unknown. Studies included in the first part of this thesis focus on the lymphatic metastatic pattern of esophageal cancer and on which lymph nodes should be removed during surgery.
An operation for esophageal cancer is a very extensive operation, as more than half of the patients undergoing this operation develop one or more complications. Studies in the second part of this thesis focus on risk factors for complications, the optimal management of postoperative complications and the consequences of complications. Lastly, predictors for long-term survival after esophagectomy for cancer are also studied. - Persistent Identifier
- https://hdl.handle.net/11245.1/9013abb5-47e7-49bb-a52a-c822fbcc78e0
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and thesis outline
Chapter 2: The extent of lymphadenectomy in esophageal resection for cancer should be standardized
Chapter 3: Distribution of lymph node metastases in esophageal carcinoma patients undergoing upfront surgery: A systematic review
Chapter 4: Differences in esophageal cancer surgery in terms of surgical approach and extent of lymphadenectomy: Findings of an international survey
Chapter 5: Distribution of lymph node metastases in esophageal adenocarcinoma after neoadjuvant chemoradiation therapy: A prospective study
Chapter 6: The impact of paratracheal lymphadenectomy on nodal yield and clinical outcomes in esophagectomy
Chapter 7: The impact of paratracheal lymphadenectomy on survival after esophagectomy: A nation-wide propensity score matched analysis
Chapter 8: Impact of lymph node yield on metastatic lymph node yield and survival in esophageal cancer surgery
Chapter 9: The evolution of surgical approach for esophageal cancer: Influence on short- and long-term outcomes
Chapter 10: Preoperative risk stratification in esophageal surgery: Comparing risk models with the clinical judgement of the surgeon
Chapter 11: Anastomotic leakage after esophagectomy for esophageal cancer: Definitions, diagnostics and treatment
Chapter 12: International survey on the management of anastomotic leakage after esophageal resection
Chapter 13: C-reactive protein as a marker for anastomotic leakage after esophageal surgery
Chapter 14: Risk factors and consequences of anastomotic leakage after esophagectomy cancer
Chapter 15: Influence of body composition and muscle strength on outcomes after multimodal esophageal cancer treatment
Chapter 16: Prognostic relevance of lymph node regression on survival in esophageal cancer: A systematic review
Chapter 17: Conditional survival after neoadjuvant chemoradiotherapy and surgery for esophageal cancer
Chapter 18: Summary
Chapter 19: Discussion and future perspectives
TIGER study protocol; Summary in Dutch (Nederlandse samenvatting); Authors and affiliations; List of publications; PhD portfolio; Acknowledgments (Dankwoord); Curriculum vitae auctoris
- Supplementary materials
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