- Author
-
P. Cernohorsky
- Title
- Illuminating the trapeziometacarpal joint
- Subtitle
- Dawn for optical coherence tomography in osteoarthritis
- Supervisors
- Co-supervisors
- Award date
- 9 June 2020
- Number of pages
- 161
- ISBN
- 9789493197053
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Osteoarthritis (OA) is a debilitating degenerative joint disease affecting millions of patients worldwide and is characterized by loss of cartilage thickness and quality in affected joints. OA of the trapeziometacarpal (TMC) joint or thumb base joint especially gives rise to loss of hand function and disability. However, clinical imaging strategies have thus far been unable to accurately assess the thin cartilage layers lining small joints like the TMC joint. Moreover, a degree of discrepancy exists between clinical symptoms and OA features as seen on clinical imaging studies, hampering treatment choice.
In an effort to eventually provide the clinician with additional and more accurate information on the status of articular cartilage in TMC OA, this thesis explores the use of Optical Coherence Tomography (OCT) in imaging of articular cartilage. OCT uses the back-reflection of near-infrared light to produce high resolution cross-sectional images. In this thesis, the use of OCT in both animal cartilage models and in-situ imaging of human cadaver TMC joints is described. The emphasis of the various studies conducted in this thesis lie on OCT signal analysis/quantification, cartilage thickness measurement comparison to reference standard imaging and co-registration/3D reconstruction of depicted joint structures. - Persistent Identifier
- https://hdl.handle.net/11245.1/8cc41793-54d8-4017-a1e6-1e7c19c68960
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Current imaging strategies in trapeziometacarpal osteoarthritis: A review
Chapter 3: Comparison of optical coherence tomography and histopathology in quantitative assessment of goat talus articular cartilage
Chapter 4: Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology
Chapter 5: In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography
Chapter 6: Computed tomography-mediated registration of trapeziometacarpal articular cartilage using intra-articular optical coherence tomography and cryomicrotome imaging: A cadaver study
Chapter 7: A probe centerline approach for automated 3D co-registration in catheter-based optical coherence tomography
Chapter 8: Concluding remarks & Future perspectives
Summary; Samenvatting
Author affiliations; PhD portfolio; List of publications; Dankwoord; About the author
Propositions
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