- Author
-
M.D. Slooter
- Title
- Dynamic fluorescence-guided surgery
- Subtitle
- The road towards defining green
- Supervisors
- Co-supervisors
- Award date
- 9 April 2021
- Number of pages
- 244
- ISBN
- 97863327398
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis addresses a number of applications of dynamic fluorescence-guided surgery. Dynamics of fluorescent agents were investigated, including an activatable fluorescent agent to detect close resection margins during oral cancer surgery, elimination by the kidneys, and tissue perfusion, also known as fluorescence angiography (FA). For FA, the aim was to evaluate time to fluorescence as a quantitative parameter to derive a threshold for patient outcomes. By adding time to FA, a continuous value provided additional information to the static fluorescence image, and allowed for quantification of perfusion in patients undergoing gastrointestinal surgery.
- Persistent Identifier
- https://hdl.handle.net/11245.1/700b229e-4468-41f7-9097-f51be54b0cec
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and thesis outline
Chapter 2: Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase
Chapter 3: Currently available and experimental dyes for intraoperative near-infrared fluorescence imaging of the ureters: A systematic review
Chapter 4: Near infrared fluorescence angiography of a pedicled omentoplasty for pelvic reconstruction: A pilot study
Chapter 5: Optimizing omentoplasty for management of chronic pelvic sepsis by intraoperative fluorescence angiography: A comparative cohort study
Chapter 6: Fluorescent imaging using indocyanine green during esophagectomy to prevent surgical morbidity: A systematic review and meta-analysis
Chapter 7: IMARI: Multi-Interventional program for prevention and early management of anastomotic leakage after low anterior resection in rectal cancer patients: Rationale and study protocol
Chapter 8: Defining indocyanine green fluorescence to assess anastomotic perfusion during gastrointestinal surgery: A systematic review
Chapter 9: Fluorescence perfusion assessment of vascular ligation during ileal pouch-anal anastomosis
Chapter 10: Quantitative fluorescence-guided perfusion assessment of the gastric conduit to predict anastomotic complications after esophagectomy
Chapter 11: Comparison of optical imaging techniques to quantitatively assess perfusion of the gastric conduit during oesophagectomy
Chapter 12: General discussion and future perspectives
Summary; Nederlandse samenvatting (Dutch summary); List of contributing authors; List of publications; PhD portfolio; Curriculum vitae; Dankwoord
- Supplementary materials
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