- Author
-
J. Liu
- Title
- Modulating diet and mitochondria to promote longevity
- Supervisors
-
R.H.L. Houtkooper
- Co-supervisors
-
A.W. Maccines
- Award date
- 4 December 2020
- Number of pages
- 268
- ISBN
- 9789464162608
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Aging is broadly defined as the time-dependent loss of functional integrity accompanied by increasing vulnerability to death with advancing age. Within the last century, improvements in health care and the discovery of antibiotics have profoundly increased human lifespan expectancy, but the age of the onset of many diseases has not been delayed significantly. Older age—generally over 65—is associated with higher risks of developing the diseases such as cancer, cardiovascular disease, diabetes, stroke, chronic inflammation, and various neurodegenerative diseases. Understanding the mechanisms underlying aging process is central to combat physiological changes that result in morbidity and mortality. Much of our understanding of the genetic basis of aging derives from studies leveraging short-lived model organisms such as yeast, worms and flies. For example, the role of nutrient sensing pathways and mitochondrial stress signaling pathways in modulating aging have been most extensively studied in worms. In addition to genetic factors, environmental signals such as exercise and diets also affect the trajectory of aging. This thesis aimed to achieve three major goals: (1) to gain more insights into the interplay between mitochondrial morphology and mitochondrial function in regulating lifespan; (2) to investigate the effects and underlying mechanisms of glycine on lifespan; (3) to search for novel factors that modulate lifespan in response to a fat diet.
- Persistent Identifier
- https://hdl.handle.net/11245.1/66b4571f-7d82-4dba-a479-69e2ff8b0e4d
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and thesis outline
Chapter 2: Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease
Chapter 3: Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Chapter 4: Glycine promotes longevity in C. elegans in a methionine cycledependent fashion
Chapter 5: Enoyl-CoA hydratase 6 modulates lifespan response to dietary excess of fat in C. elegans
Chapter 6: Engineering a high-fat bacterial diet for metabolic aging research in C. elegans
Chapter 7: Discussion and future perspectives
Chapter 8: Summary
Abbreviations; Authors' contributions; Authors' affiliations; List of publications; PhD portfolio; Acknowledgement; About the author
- Supplementary materials
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.