- Author
-
J. Yang
- Title
- The role of the complement and contact systems in asthma
- Supervisors
-
T. van der Poll
E.H.D. Bel - Co-supervisors
-
C. van 't Veer
- Award date
- 27 May 2020
- Number of pages
- 200
- ISBN
- 9789493184411
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
For a long time asthma has been regarded as a lung disease associated with lung inflammation, airflow obstruction, coughing and mucus hypersecretion. Since their introduction 30 years ago, Inhalation corticosteroids and bronchodilators are still the cornerstone of asthma management nowadays, indicating that advancement in this field has somewhat stagnated. In recent years, we have started to appreciate that underneath the similar set of symptom manifestations, the asthma syndrome encompasses complex and heterogeneous pathophysiological mechanisms. The biologicals targeting specific type 2 cytokines have shown great clinical improvements in asthmatic patients and exemplify the importance of targeted therapy to advance asthma management.
This thesis can be regarded as a continuous effort to identify undiscovered pathophysiological traits in asthma. We here investigated the therapeutic potential of C1-inhibitor in both human and murine asthma models, considering that C1-inhibitor exerts immunomodulatory effects as a regulator of both the complement and contact system. These systems have been implicated to play a role in the pathogenesis and pathophysiology of asthma, making them interesting for further research to elucidate their potential as candidates for targeted therapy. - Note
- Title on cover: The role of the complement and contact systems in allergic asthma
- Persistent Identifier
- https://hdl.handle.net/11245.1/4130f823-da0b-4b9b-815f-6b35737539d5
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Effect of C1-inhibitor in adults with mild asthma: a randomised controlled trial
Chapter 3: Transcriptional changes in alveolar macrophages from adults with asthma after intrabronchial allergen challenge
Chapter 4: Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice
Chapter 5: Complement C3a receptor signaling is not involved in the migration and degranulation of murine eosinophils
Chapter 6: Complement C5 inhibition reduces TH2 cells but not ILCs in a house dust mite induced murine asthma model
Chapter 7: Mast cell-deficient Kit w-sh mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment
Chapter 8: Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII
Chapter 9: Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model
Chapter 10: Summary and general discussion
Chapter 11: Nederlandse samenvatting
Authors and affiliations; Publication list; Portfolio; About the author; Dankwoord
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