- Author
-
C.S. Bruikman
- Title
- Familial atherosclerosis and neuroimmune guidance cues
- Subtitle
- From in vitro assessments to clinical events
- Supervisors
- Co-supervisors
-
J.M. van Gils
- Award date
- 26 June 2020
- Number of pages
- 197
- ISBN
- 9789463758857
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
The aim of the studies described in this thesis was twofold: 1) to substantiate the role of Neuroimmune Guidance Cues (NGCs) in human atherosclerotic disease and 2) to further improve treatment strategies for families where premature atherosclerosis is prevalent.
This thesis demonstrates Neuroimmune Guidance Cues to play a role in human atherosclerosis and in particular Netrin-1 seems to have the most potential to become a new therapeutic target within cardiovascular disease. In addition, it is important to identity unaffected relatives at risk within families suffering from premature atherosclerosis because they most likely benefit from additional testing for cardiovascular risk. - Persistent Identifier
- https://hdl.handle.net/11245.1/33583578-66bd-4143-824c-27a30d63d097
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and outline of the thesis
Chapter 2: Understanding netrins in endothelial cell biology
Chapter 3: Eph receptor B2 stimulates human monocyte adhesion and migration independently of its ephrinB ligands
Chapter 4: Downregulation of endothelial PLXNA4 under pro-atherosclerotic conditions diminishes vascular integrity
Chapter 5: Netrin-1 and the grade of atherosclerosis are inversely correlated in humans
Chapter 6: Netrin-1 in coronary artery disease: Mechanism of action and potential as therapeutic target
Chapter 7: The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis
Chapter 8: Sudden cardiac death in families with premature cardiovascular disease
Chapter 9: Summary and future perspectives
Nederlandse samenvatting; Co-authors and affiliations; PhD portfolio; Dankwoord; About the author; Nawoord
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