- Author
-
M.A. Kempeneers
- Title
- Clinical course and treatment of chronic pancreatitis
- Supervisors
-
M.A. Boermeester
M.G.H. Besselink - Co-supervisors
-
H.C. van Santvoort
Y. Issa - Award date
- 23 April 2021
- Number of pages
- 294
- ISBN
- 9789464231670
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Chronic pancreatitis is still for a large part shrouded in mists. Although chronic pancreatitis was first described around 1800 and since then over 20.000 research articles are published on this topic, there are still many knowledge gaps and misunderstandings regarding diagnostics, course of disease and treatment of chronic pancreatitis. Comprehensive understanding of chronic pancreatitis is needed to understand and successfully treat a patient with chronic pancreatitis. As such, this thesis aims to fulfill several knowledge gaps in chronic pancreatitis. The first part of the thesis explores the diagnostics and natural course of chronic pancreatitis, whereas the second part focusses on the surgical treatment of chronic pancreatitis.
- Persistent Identifier
- https://hdl.handle.net/11245.1/311ce2d8-85c7-4d62-a27d-659ab1a5b193
- Downloads
-
Thesis (complete)
Front matter
General introduction and outline of the thesis
Chapter I: Diagnostic performance of imaging modalities in chronic pancreatitis: A systematic review and meta-analysis
Chapter II: Natural course and treatment of pancreatic exocrine insufficiency in a nationwide cohort of chronic pancreatitis
Chapter III: A classification algorithm for types of diabetes in chronic pancreatitis using epidemiological characteristics: Outcome in a longitudinal cohort study
Chapter IV: Pain patterns in chronic pancreatitis: A nationwide longitudinal cohort study
Chapter V: Controversies on the endoscopic and surgical management of pain in patients with chronic pancreatitis: Pros and cons!
Chapter VI: International consensus guidelines for surgery and the timing of intervention in chronic pancreatitis
Chapter VII: Short- and long-term outcomes of selective use of either Frey or extended lateral pancreaticojejunostomy in chronic pancreatitis
Chapter VIII: Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis: The ESCAPE randomized clinical trial
Chapter VIII-II: Standardized endoscopy strategy for better control of painful chronic pancreatitis: Reply
Chapter IX: Cost-effectiveness of early surgery vs endoscopy-first approach for painful chronic pancreatitis in the ESCAPE trial
Chapter X: Efficacy of total pancreatectomy with islet autotransplantation on opioid and insulin requirement in painful chronic pancreatitis: A systematic review and meta-analysis
Chapter XI: Summary
Chapter XII: General discussion and future perspectives
Chapter XIII: Nederlandse samenvatting
List of publications; List of contributing authors; PhD portfolio; Dankwoord; Curriculum vitae
- Supplementary materials
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