- Author
-
L. Brouwer
- Title
- The peculiar story of the ubiquitous Enterovirus and its enigmatic companion, the Parechovirus
- Supervisors
-
M.D. de Jong
- Co-supervisors
-
K.C. Wolthers
D. Pajkrt - Award date
- 1 October 2020
- Number of pages
- 234
- ISBN
- 9789464210033
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Enteroviruses (EVs) and parechoviruses (PeVs) are highly prevalent viruses worldwide. Together, these groups contain over 120 different virus types, that cause a wide spectrum of disease in humans. Several types - such as poliovirus, EV-A71, EV-D68 and PeV-A3 – have caused large outbreaks of severe disease over the past decades. However, most EV and PeV infections remain subclinical. The many EV and PeV types show complicated circulation patterns that change over time and differ per geographic region. As a result, our knowledge on the epidemiology of these large groups of viruses is limited. The aim of this thesis is to increase our insight in the epidemiology of EVs and PeVs by studies on their prevalence, seroprevalence and molecular epidemiology in several populations.
- Persistent Identifier
- https://hdl.handle.net/11245.1/253002b5-8920-4f29-b4eb-20a532034dc7
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: Introduction
Chapter 2: World-wide prevalence and genotype distribution of enteroviruses
Chapter 3: High frequency of Enterovirus C strains in a cohort of Malawian children
Chapter 4: Recombination analysis of non-poliovirus members of the Enterovirus C species; Restriction of recombination events to members of the same 3Dpol cluster
Chapter 5: Seroepidemiology of seven echoviruses in the Netherlands
Chapter 6: World-wide prevalence and genotype distribution of Parechovirus A
Chapter 7: Parechovirus A prevalence in adults in the Netherlands
Chapter 8: High frequency and diversity of Parechovirus A in a cohort of Malawian children
Chapter 9: Seroepidemiology of Parechovirus A3 neutralizing antibodies, Australia, the Netherlands, and United States
Chapter 10: Summary
Chapter 11: Discussion
Samenvatting; List of publications; Author affiliations; About the author; PhD portfolio; Acknowledgements
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