- Author
-
M.C.R. Gumbs
- Title
- Brain circuitries in control of feeding behaviors
- Subtitle
- Focus on Neuropeptide Y
- Supervisors
-
J. Booij
S.E. la Fleur - Co-supervisors
- Award date
- 5 February 2020
- Number of pages
- 282
- ISBN
- 9789402818789
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
The modern-day food environment, with relatively easy and unlimited access to foods high in fat and sugar, contributes strongly to the etiology of obesity by disrupting peripheral and central mechanisms that control energy homeostasis. The free-choice high-fat high-sucrose diet has high clinical validity to model human diet-induced obesity. In this diet model, the orexigenic Neuropeptide Y (NPY) system is paradoxically upregulated in the hypothalamus, a key brain area involved in caloric intake and energy homeostasis. In addition, the function of key reward-related brain areas is also altered by chronic consumption of the free-choice high-fat high-sucrose diet. The first aim of this thesis was to further characterize diet-induced functional changes in the NPY system and the reward-related brain circuitry. The second aim of this thesis was to determine the neuroanatomical connection between the NPY system and key reward-related brain areas. Given that multiple brain areas express NPY, the origin of NPY that signals in the reward-related system was systematically determined. Using a combination of molecular, neuroanatomical, histological and pharmacological techniques, the studies in this thesis have provided new insight into the organization of the brain NPY system and its disruption by chronic consumption of an obesogenic diet.
- Persistent Identifier
- https://hdl.handle.net/11245.1/163aeb85-0675-4be4-9d47-75658b20a169
- Downloads
-
Thesis (complete)
Front matter
Chapter I: Introduction
Chapter II: The effect of obesogenic diets on the NPY system
Chapter III: Long-term consumption of a free choice high-fat high-sugar diet affects NPY-related gene expression in a brain region-specific manner
Chapter IV: Effects of a 24-hour acute fast on NPY-related gene expression in hypothalamic and mesolimbic brain regions
Chapter V: Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity
Chapter VI: Neuropeptide Y signaling in the lateral hypothalamus modulates diet component selection and is dysregulated in a model of diet-induced obesity
Chapter VII: Dietary choice and composition modulate the orexigenic effects of Neuropeptide Y in the lateral hypothalamus of the male Wistar rat
Chapter VIII: Afferent Neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats
Chapter IX: A 24 hour fast differentially affects dopaminergic and opioid gene expression
Chapter X: Pilot study: Predicting striatal DRD2/3 availability from the inhibitory effect of dexamphetamine on feeding
Chapter XI: Summary and general discussion
References; Appendices; Acknowledgements - Dankwoord; About the author
Propositions; Stellingen
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