- Author
-
A. Masís Vargas
- Title
- Metabolic and physiologic effects of acute exposure to artificial light at night
- Supervisors
- Award date
- 4 February 2021
- Number of pages
- 253
- ISBN
- 9789464211962
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis investigated the metabolic and physiologic effects of acute exposure to artificial light at night (ALAN) in nocturnal and diurnal rodents. White and blue light caused glucose intolerance and affected food intake in a sex- and wavelength-dependent manner in Arvicanthis. In rats, we observed effects of light in locomotor activity (LA), energy expenditure (EE), respiratory exchange ratio (RER), food intake, and hepatic expression of clock and metabolic genes in a time- and wavelength-dependent fashion. In mice, white and blue light decreased LA; when fed a free-choice high fat high-sucrose diet an improved glucose tolerance was observed after light exposure. HFHS-fed animals exposed to blue light increased fat intake. Both wavelengths increased chow food intake when we used melanopsin mutant mice. Mice exposed to ALAN showed an altered EE, RER, and plasma glucose levels in a time-dependent manner. We showed that an intact molecular clock is necessary to observe metabolic disturbances caused by ALAN using BMAL1 -/- mice. These effects were dependent on the wavelength, indicating that ipRGCs, cones, and rods may be part of the pathways involved. We provided further evidence on the need for caution when being exposed to ALAN, to prevent detrimental metabolic consequences.
- Persistent Identifier
- https://hdl.handle.net/11245.1/1569279b-5f52-40fb-80bc-96b266027ded
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and scope of the thesis
Chapter 2: Metabolic implications of exposure to light at night: A compilation of animal and human evidence
Chapter 3: White light decreases glucose tolerance and reduces sugar and fat consumption in Arvicanthis ansorgei
Chapter 4: Exposure to blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sexdependent manner
Chapter 5: Metabolic effects of light at night are time‐ and wavelength‐dependent in rats
Chapter 6: Blue light at night modulates glucose metabolism and increases fat intake in female mice fed a free choice high-fat high-sucrose diet
Chapter 7: Acute effects of different wavelengths and time exposures of light at night in the metabolism of wild type and BMAL1 -/- mice
Chapter 8: General discussion and future perspectives
Summary; Samenvatting; Résumé de la thèse; PhD portfolio; Acknowledgments/Agradecimientos; About the author/Acerca de la autora
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.