- Author
-
S. van Roessel
- Title
- Clinicopathological outcome and prognostication in pancreatic surgery
- Supervisors
- Co-supervisors
-
J. Verheij
B. Groot Koerkamp - Award date
- 2 October 2020
- Number of pages
- 329
- ISBN
- 9789463759700
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis mainly encompasses studies aimed to improve oncological and surgical treatment of pancreatic head cancer and other periampullary cancers in relation to short-term clinical and long-term oncological outcome. Many studies are a collaboration between multiple centers, either within the nationwide Dutch Pancreatic Cancer Group (DPCG) or as international collaboration, both within or outside Europe. Part I comprises three chapters, outlining the surgical and oncological outcomes of pancreatic surgery in a single-center study, a nationwide study and an international cohort study. The five chapters in Part II mainly focus on the challenges encountered in the pathology assessment of a surgical specimen following pancreatic surgery. The five chapters in Part III evaluate the prognostic significance of several prediction models and staging systems for pancreatic and other periampullary cancers. The prediction models were made available on the website www.pancreascalculator.com.
- Persistent Identifier
- https://hdl.handle.net/11245.1/0680392a-c8b5-4722-bdc6-146492252d2c
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and outline of this thesis
Chapter 2: Textbook outcome: Nationwide analysis of a novel quality measure in pancreatic surgery
Chapter 3: Impact of expanding indications on surgical and oncological outcome in 1,434 consecutive pancreatoduodenectomies
Chapter 4: Adjuvant chemotherapy in patients with resected pancreatic cancer after neoadjuvant FOLFIRINOX: An international multicenter retrospective cohort
Chapter 5: Pathological margin clearance and survival after pancreaticoduodenectomy in a US and European pancreatic center
Chapter 6: Preoperative misdiagnosis of pancreatic and periampullary cancer in patients undergoing pancreatoduodenectomy: A multicenter cohort study
Chapter 7: Axial slicing versus bivalving in the pathological examination of pancreatoduodenectomy specimens (APOLLO): A multicenter randomized controlled study
Chapter 8: Systematic review of histological tumour response scoring in resected pancreatic cancer following preoperative chemo(radio)therapy
Chapter 9: Amsterdam international consensus meeting: Pathology assessment following neoadjuvant therapy in resected pancreatic cancer
Chapter 10: International validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM staging system in patients with resected pancreatic cancer
Chapter 11: International validation and update of the Amsterdam model for prediction of survival after pancreatoduodenectomy for pancreatic cancer
Chapter 12: Conditional survival after resection for pancreatic cancer: A population-based study and prediction model
Chapter 13: Development and validation of a prognostic prediction model for overall survival in patients with distal cholangiocarcinoma after receiving pancreatoduodenectomy with curative intent: An international multicenter study
Chapter 14: Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma
Chapter 15: Summary
Chapter 16: General discussion and future perspectives
Nederlandse samenvatting; List of publications; List of contributing authors; PhD portfolio; Dankwoord; Curriculum vitae
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.