- Author
-
M.E. van Hezel
- Title
- Effect of red cell transfusion on the host immune response in critically ill patients
- Supervisors
-
N.P. Juffermans
M.J. Schultz - Co-supervisors
-
R. van Bruggen
- Award date
- 28 February 2020
- Number of pages
- 235
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
In this thesis we investigated the effect of RBC transfusion on the host immune response. We conclude that RBC transfusions in critically ill patients are associated with an inflammatory and procoagulant host response. Activated neutrophils, monocytes, platelets and endothelium cells are likely to be involved in this complex response, which seems stronger when an inflammatory status is present in the recipient. We hypothesize that RBC derived EVs are potent mediators of the association between RBC transfusion and the host response. There are multiple opportunities for further improvement of clinical practice as well as of the RBC product, with the aim to reduce immune modulating effects of RBC transfusion.
- Persistent Identifier
- https://hdl.handle.net/11245.1/05dd8895-b39e-4322-be01-1d506fcd23fd
- Downloads
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.