- Author
-
P. Chichareon
- Title
- Risk stratification and prediction in patients with coronary artery disease undergoing contemporary revascularization
- Supervisors
-
J.J. Piek
P.W.J.C. Serruys - Co-supervisors
-
J.J. Wykrzykowska
Y. Onuma - Award date
- 27 May 2020
- Number of pages
- 606
- ISBN
- 9789463614115
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Myocardial revascularization is a mainstay for the treatment of acute coronary syndrome and has been proved to enhance the survival of the patients. In chronic coronary syndrome, myocardial revascularization plays a role as adjunctive therapy to optimal medical therapy. Not every coronary artery disease patient is the same. Patients can be different in terms of clinical characteristics, disease complexity, personal perception of the disease, and preference for the treatment. Many of these factors contribute to the outcomes of the patients after revascularization. Personalized care by taking all relevant factors into account is the ultimate goal of the current practice.
Risk stratification and risk score contribute to the prediction of the occurrence of adverse events and help in selecting patients with high risk for the interesting events and ultimately aim at delivering tailor-made treatment to the individual patient. The characteristics of the patients presenting with coronary artery disease are changing as a consequence of the increased lifespan of the population, and the treatment has been evolving. These aspects may alter the prognosis of the patients and may affect the performance of the risk stratification or predictive models. Therefore, the impact of clinical and procedural characteristics and treatment on patients’ outcomes should be reassessed in contemporary practice.
Risk stratification and prediction are not static but need to be dynamic to avoid being declared obsolete or outdated. In this thesis, we provide an insight to the risk stratification and prediction of coronary artery disease patients undergoing revascularization in contemporary practice. - Persistent Identifier
- https://hdl.handle.net/11245.1/013a4cb4-d789-4c93-ac0e-d506011ddece
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction and outline of the thesis
Chapter 2: Risk stratification and risk scores in chronic ischemic heart disease
Chapter 3: Predictive ability of ACEF and ACEF II score in patients undergoing percutaneous coronary intervention in the GLOBAL LEADERS study
Chapter 4: Are contemporary risk scores better at predicting 30-day all-cause mortality after PCI than the parsimonious ACEF score?
Chapter 5: DAPT score and the impact of ticagrelor monotherapy during the second year after PCI
Chapter 6: Validation of the updated logistic clinical SYNTAX score for all-cause mortality in GLOBAL LEADERS trial
Chapter 7: Impact of non-respect of SYNTAX score II recommendations for surgery in patients with left main coronary artery disease treated by percutaneous coronary intervention: an EXCEL substudy
Chapter 8: Association of sex with outcomes in patients undergoing percutaneous coronary intervention: A subgroup analysis of the GLOBAL LEADERS randomized clinical trial
Chapter 9: Association of diabetes with outcomes in patients undergoing contemporary percutaneous coronary intervention: Pre-specified subgroup analysis from the randomized GLOBAL LEADERS study
Chapter 10: Impact of established cardiovascular disease on outcomes in the randomised GLOBAL LEADERS trial
Chapter 11: Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial
Chapter 12: Impact of long-term ticagrelor monotherapy following one-month dual antiplatelet therapy in patients who underwent complex percutaneous coronary intervention: insights from the GLOBAL LEADERS trial
Chapter 13: Efficacy and safety of ticagrelor monotherapy in patients undergoing multivessel PCI
Chapter 14: Efficacy and safety of stents in ST-segment elevation myocardial infarction: Individual patient data network meta-analysis
Chapter 15: Benefit and risks of aspirin in addition to ticagrelor in acute coronary syndromes: A post hoc analysis of the randomized GLOBAL LEADERS trial
Chapter 16: Association between post-percutaneous coronary intervention bivalirudin infusion and net adverse clinical events: A post-hoc analysis of the GLOBAL LEADERS study
Chapter 17: Contemporary outcomes following coronary artery bypass graft surgery for left main disease
Chapter 18: Predicting 2-year all-cause mortality after contemporary PCI: updating the logistic clinical SYNTAX score
Chapter 19: The SYNTAX score on its way out or … toward artificial intelligence: part I
Chapter 20: The SYNTAX score on its way out or … toward artificial intelligence: part II
Authors and affiliations; Curriculum vitae; Portfolio; List of publications; Acknowledgement
Disclaimer/Complaints regulations
If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library, or send a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.