- Author
-
E.C.E. Meessen
- Title
- Postprandial human bile acids
- Subtitle
- A gut feeling
- Supervisors
-
J.A. Romijn
A.K. Groen - Co-supervisors
-
M.R. Soeters
E.M. Kemper - Award date
- 26 March 2021
- Number of pages
- 227
- ISBN
- 9789492332318
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This dissertation encompasses different translational observational- and intervention studies in which we investigated the postprandial bile acid response, using mixed meal tests in healthy individuals and patients with type 2 diabetes mellitus. In part 1, we reviewed the physiology of the postprandial (inflammatory) response and the anti-inflammatory effects of bile acids. Part 2 contains three observational studies where we focused on the postprandial bile acid responses under different “physiological” conditions including day-to-day variability, fasting and intravenous meal infusion. In part 3, we aimed to improve metabolic health via the modulation of postprandial bile acid responses with different interventions. Finally, in part 4, we discussed some topics which are relevant for translational bile acid research and its clinical impact.
- Note
- Please note that the sections 'Portfolio', 'Curriculum vitae' and 'Dankwoord' are not included in the thesis downloads.
- Persistent Identifier
- https://hdl.handle.net/11245.1/d231a3e2-6dba-4210-abf1-501b5d8be81e
- Downloads
-
Thesis
Front matter
Chapter 1: A short introduction in bileology & thesis outline
Chapter 2: Human postprandial nutrient metabolism and low-grade inflammation: A narrative review
Chapter 3: Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine
Chapter 4: Differential effects of a 40 hour fast and bile acid supplementation on human GLP-1 and FGF19 responses
Chapter 5: Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men
Chapter 6: Differential effects of one meal per day in the evening on metabolic health and physical performance in healthy lean volunteers
Chapter 7: Duodenal mucosal resurfacing with GLP-1 receptor agonism increases postprandial unconjugated bile acids responses in patients with insulin-dependent type 2 diabetes mellitus
Chapter 8: Transintestinal cholesterol excretion in humans
Chapter 9: Safety and metabolic effects of glycodeoxycholic acid in healthy lean men: A proof of concept study
Chapter 10: General discussion: More than a gut feeling
Chapter 11: Summary
Chapter 12: Nederlandse samenvatting
Contributing authors’ affiliations
- Supplementary materials
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