- Author
-
R. Indrakusuma
- Title
- Exploring the trinity of risks in abdominal aortic aneurysms
- Supervisors
-
R. Balm
- Co-supervisors
-
M.J.W. Koelemay
R.N. Planken - Award date
- 11 February 2020
- Number of pages
- 244
- ISBN
- 9789463806749
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis explores the three main risks that are relevant in the management of patients with an abdominal aortic aneurysm (AAA). These risks are the risk of rupture, procedural risks and competing risks and will need to be weighed against each other to tailor the treatment decision to the individual patient. However, making this decision can sometimes be a challenge because it is often difficult to accurately estimate either of these risks. Therefore, any improvement in estimating these risks may help both the vascular surgeon and the patient in making this decision. The first part of this thesis is focused on evaluating biomechanical imaging markers that could potentially be used to estimate rupture risk. The existing literature was critically reviewed in order to determine potentially useful biomechanical imaging markers and a magnetic resonance imaging (MRI) study was undertaken to assess the reproducibility of 4D flow MRI. Part two of this thesis primarily consists out of retrospective cohort studies that evaluated whether certain determinants for procedural and competing risks could be relevant for clinical practice. The final part considers AAA research and the challenges regarding the three risks. It presents the design and protocol of the biobank ‘Pearl AAA’ which was initiated in order to address some of these challenges. Specifically, it is aimed to recruit patients with a small asymptomatic AAA of whom clinical data, imaging data and biomaterials are collected for future study.
- Note
- Please note that the sections 'Acknowledgements - Dankwoord' and 'Curriculum vitae' are not included in the thesis downloads.
- Persistent Identifier
- https://hdl.handle.net/11245.1/5cce50d9-163e-4799-8968-2c9f16691d3f
- Downloads
-
Thesis
Front matter
Chapter 1: Biomechanical imaging markers as predictors of abdominal aortic aneurysm growth or rupture: A systematic review
Chapter 2: Wall shear stress estimation in abdominal aortic aneurysms using 4D flow MRI: Feasibility, reproducibility, inter- and intra-observer agreement
Chapter 3: Psoas muscle area as a prognostic factor for survival in patients with an asymptomatic infrarenal abdominal aortic aneurysm: A retrospective cohort study
Chapter 4: Sex-related differences in perioperative mortality after elective repair of an asymptomatic abdominal aortic aneurysm in the Netherlands: Retrospective analysis of 2013 to 2018
Chapter 5: Prophylactic mesh reinforcement versus sutured closure to prevent incisional hernias after open abdominal aortic aneurysm repair via midline laparotomy: A systematic review and meta-analysis
Chapter 6: Long-term survival after acute kidney injury following ruptured abdominal aortic aneurysm repair
Chapter 7: Reporting of complications and mortality in relation to risk communication in patients with an abdominal aortic aneurysm: A systematic review
Chapter 8: Design and protocol of a comprehensive multicentre biobank for abdominal aortic aneurysm
Chapter 9: Applying the framework of contextual integrity to compare requirements on consent between the General Data Protection Regulation and the European Data Protection Board for clinical biobanks
Thesis summary; Future perspectives; Nederlandse samenvatting en toekomstperspectieven; PhD portfolio
Stellingen
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