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- Author
-
L.L. van Wanrooij
- Title
- Apathy and cognitive decline in clinical studies of older persons
- Supervisors
-
W.A. van Gool
E. Richard - Co-supervisors
- Award date
- 1 July 2021
- Number of pages
- 152
- ISBN
- 9789464166552
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis consists of several
clinical studies of which the overarching theme isapathy and cognitive decline in older persons Cox analyses were used to subjective memory complaints and two simple memory task scores with future dementia. A combination of tests that can be administered in about ten minutes, provedstudy useful for identifying increased risk for dementia. Again using cox analyses,older persons the second symptoms, independently and in isolation, are associated with future dementia, although thestudy showed that bothapathy and associations are stronger for network analysis was used to dive deeper into theapathy complex relationships between disability, subjective memory complaints and future dementia. Using this novel method, associations between individual network items could be found while controlling for relations between other items. Then, in a prospective cohortapathy study , the courseof post-strokeapathy in relation tocognitive concluded that need separate monitoring and treatment in rehabilitation programs for stroke survivors. Finally, information loss as a result of processes to recode variables was studied, an initiative oftenapathy and cognitive decline taken to pool data from regression models on data from three randomized controlled trials and on simulated data, it was found that information loss is most prominent for variables that have been recoded from continuous to discrete, which may impact subsequent in-depth pooled analyses.clinical - Persistent Identifier
- https://hdl.handle.net/11245.1/5946f08b-0c5e-4657-80d7-383f7fb8ca9c
- Downloads
-
Thesis (complete)
Front matter
Chapter I: General introduction and thesis outline
Chapter II: Associations of subjective memory complaints and simple memory task scores with future dementia in the primary care setting
Chapter III: Apathy is associated with incident dementia in community-dwelling older people
Chapter IV: A network approach on the relation between apathy and depression symptoms with dementia and functional disability
Chapter V: The course of post-stroke apathy in relation to cognitive functioning: A prospective cohort study
Chapter VI: Pooling individual participant data from randomized controlled trials: Exploring potential loss of information
Chapter VII: General discussion, future perspectives and conclusions
Summary; Nederlandse samenvatting (Dutch summary); List of publications; List of contributing authors; PhD portfolio; Dankwoord/Acknowledgements; About the author
- Supplementary materials
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