- Author
-
G. de Jong
- Title
- Treasures from nature
- Subtitle
- From natural antibody responses to novel immunotherapies for cancer
- Supervisors
-
M.D. Hazenberg
H. Spits - Co-supervisors
-
P.M.Q. van Helden
- Award date
- 13 January 2021
- Number of pages
- 187
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
The starting point of this thesis was the contention that exploring the B-cell immune response of cancer patients who have responded exceptionally well to immunotherapy, can lead to new immunotherapeutic options for cancer. The work focusses on acute myeloid leukemia (AML), the hematopoietic malignancy that can most often only be cured when an allogeneic hematopoietic cell transplantation (HCT) is performed to induce a graft-versus-leukemia (GvL) immune response. Various immune cell types play a part in the GvL response, of which B cells had our particular interest. B cells carry the code for unique immunoglobulins that recognize native antigen, and accordingly these antibodies can be used to target said antigen. Thus, by studying the B cells of long-term tumor-free patients in order to find tumor-reactive B cells, we aimed to identify new leads for therapy.
- Persistent Identifier
- https://hdl.handle.net/11245.1/1e0ff815-80a6-4c1d-bd06-c16205ace907
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: Introduction
Chapter 2: Survival of early post-hematopoietic stem cell transplantation relapse of myeloid malignancies
Chapter 3: AML relapse after rituximab treatment for graft-versus‑host disease: Crucial role for B cells in graft-versus-leukemia responses
Chapter 4: A patient derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice
Chapter 5: A chemo-enzymatically linked bispecific antibody retargets T cells to a sialylated epitope on CD43 in acute myeloid leukemia
Chapter 6: Melanoma cells can be eliminated by sialylated CD43 x CD3 bispecific T cell engager formats in vitro and in vivo
Chapter 7: A patient-derived antibody effectively targets B-ALL in vivo via a unique epitope on CD9 without inducing thrombosis
Chapter 8: Discussion: Tumor-reactive B cells and antibody responses after allogeneic hematopoietic cell transplantation
Chapter 9: Summary and epilogue
Nederlandse samenvatting; List of authors and affiliations; Portfolio; List of publications; Dankwoord; About the author
- Supplementary materials
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